资源类型

期刊论文 22

年份

2023 1

2022 3

2021 2

2019 3

2018 1

2015 1

2014 2

2012 4

2010 1

2008 1

2007 1

2006 1

2001 1

展开 ︾

关键词

“白箱”模型 1

一次原因分析法 1

中国航天白皮书 1

人工智能诊断 1

多孔碳 1

大航天 1

实时监测网络 1

微波吸收 1

氧化铝 1

状态转移方程 1

生物质 1

白光X射线衍射 1

白炭黑 1

碳酸钾 1

筛选法 1

粉煤灰 1

综合利用 1

能量色散X射线衍射 1

能量色散阵列探测器 1

展开 ︾

检索范围：

排序： 展示方式：

Medical applications of phytoestrogens from the Thai herb

null

《医学前沿（英文）》 2012年 第6卷 第1期   页码 8-21 doi: 10.1007/s11684-012-0184-8

摘要：

Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.

关键词： white Kwao Krua     miroestrol     estrogenic activity     reproduction     osteoporosis     breast cancer     Alzheimer    

HTML PDF 收藏

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

《医学前沿（英文）》 2021年 第15卷 第6期   页码 887-902 doi: 10.1007/s11684-021-0879-9

摘要： Monocarboxylic acid transporter 1 (MCT1) maintains axonal function by transferring lactic acid from oligodendrocytes to axons. Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear. In this study, the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury after SAH. At 48 h after SAH, oligodendrocyte MCT1 was significantly reduced, and the exogenous overexpression of MCT1 significantly improved white matter integrity and long-term cognitive function. Motor training after SAH significantly increased the number of ITPR2+SOX10+ oligodendrocytes and upregulated the level of MCT1, which was positively correlated with the behavioral ability of rats. In addition, miR-29b and miR-124 levels were significantly increased in SAH rats compared with non-SAH rats. Further intervention experiments showed that miR-29b and miR-124 could negatively regulate the level of MCT1. This study confirmed that the loss of MCT1 may be one of the mechanisms of white matter damage after SAH and may be caused by the negative regulation of miR-29b and miR-124. MCT1 may be involved in the neurological improvement of rehabilitation training after SAH.

关键词： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

HTML PDF 收藏

Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

《化学科学与工程前沿（英文）》 2012年 第6卷 第2期   页码 216-223 doi: 10.1007/s11705-012-1289-y

摘要： White spot syndrome virus (WSSV) is a major cause of high mortality in cultured shrimp all over the world. VP26 is one of the structural proteins of WSSV that is assumed to assist in recognizing its host and assists the viral nucleocapsid to move toward the nucleus of the host cell. The objective of this work was to produce a polyclonal antibody against VP26 and use it as a biosensor. The recombinant VP26 protein (rVP26) was produced in (BL21), purified and used for immunizing rabbits to obtain a polyclonal antibody. Western blot analysis confirmed that the antiserum had a specific immunoreactivity to the VP26 of WSSV. This VP26 antiserum was immobilized onto a gold electrode for use as the sensing surface to detect WSSV under a flow injection system. The impedance change in the presence of VP26 was monitored in real time. The sensitivity of the biosensor was in the linear range of 160–160000 copies of WSSV, indicating that it is good and sensitive for analysis of WSSV. The specificity of the biosensor was supported by the observation that no impedance change was detected even at high concentrations when using Yellow Head Virus (YHV). This biosensor may be applied to monitor the amount of WSSV in water during shrimp cultivation.

关键词： recombinant protein     polyclonal antibody     label-free biosensor     impedance     white spot syndrome virus (WSSV)    

HTML PDF 收藏

A microarray study of altered gene expression during melanoblasts migration in normal pigmented White

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

《农业科学与工程前沿（英文）》 2014年 第1卷 第4期   页码 299-306 doi: 10.15302/J-FASE-2014040

摘要： Melanoblasts originating from neural crest cells can migrate through the mesenchyme of the developed embryo and give rise to melanocytes. Unlike the melanocytes that are confined to the integument in other vertebrates, melanocytes in Silky Fowl can reach the ventral regions of the embryos owing to differences in gene expression in the process of melanoblasts migration. In this study, we used microarray profiling to identify differences in gene expression between White Leghorn and Silky Fowl. Differential expression of 2517 microarray probes ( <0.01, Fold Change>2) was observed in Silky Fowl compared to White Leghorn. After filtration by cluster analysis, functional annotation and pathway analysis, eight differentially expressed genes were identified to be closely related to the development of melanocytes. Moreover, differences in expression of immune genes were also detected between Silky Fowl and White Leghorn. The differentially expressed genes associated with melanocyte development were verified by q-PCR, and results were highly consistent with the microarray data. The genes with significantly altered expression involved in melanoblast migration and development suggested that different microenvironments resulted in the abnormal melanoblast migration in Silky Fowl, although there were no big differences in melanoblast development between these two breeds. The candidate genes discovered in this study are beneficial to understand the molecular mechanism of hyperpigmentation in Silky Fowl.

关键词： Silky Fowl     White Leghorn     melanoblast migration     gene expression    

HTML PDF 收藏

control of structural responses using an optimal passive tuned mass damper under stationary Gaussian white

Min-Ho CHEY, Jae-Ung KIM

《结构与土木工程前沿（英文）》 2012年 第6卷 第3期   页码 267-280 doi: 10.1007/s11709-012-0170-x

摘要： In this study, the structural control strategy utilizing a passive tuned mass damper (TMD) system as a seismic damping device is outlined, highlighting the parametric optimization approach for displacement and acceleration control. The theory of stationary random processes and complex frequency response functions are explained and adopted. For the vibration control of an undamped structure, the optimal parameters of a TMD, such as the optimal tuning frequency and optimal damping ratio, to stationary Gaussian white noise acceleration are investigated by using a parametric optimization procedure. For damped structures, a numerical searching technique is used to obtain the optimal parameters of the TMD, and then the explicit formulae for these optimal parameters are derived through a sequence of curve-fitting schemes. Using these specified optimal parameters, several different controlled responses are examined, and then the displacement and acceleration based control effectiveness indices of the TMD are examined from the view point of RMS values. From the viewpoint of the RMS values of displacement and acceleration, the optimal TMDs adopted in this study shows clear performance improvements for the simplified model examined, and this means that the effective optimization of the TMD has a good potential as a customized target response-based structural strategy.

关键词： tuned mass damper     parametric optimization     passive control     white noise     earthquake excitation    

HTML PDF 收藏

reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

《农业科学与工程前沿（英文）》 2018年 第5卷 第3期   页码 373-381 doi: 10.15302/J-FASE-2018210

摘要：

Egg white proteins are one of the major allergens. The objective of this study was to investigate the effect of Aspergillus oryzae cultivation on IgE binding ability of egg white proteins. Effect of A. oryzae on egg white proteins was determined using ninhydrin method, SDS-PAGE, ELISA, fluorescence FITC labeling, MALDI-TOF-MS and LC-MS/MS analysis. Adding mycelium of A. oryzae ATCC 1011 and 16868 substantially reduced the IgE binding ability of acidified egg white after 24 h incubation. The binding capacity of egg white proteins to IgE in plasma from four egg allergy patients was almost completely lost after incubation with mycelium of ATCC 16868. Results from SDS-PAGE, free amino acid analysis, MALDI-TOF-MS and LC-MS/MS indicated that there was no substantial protein degradation during incubation. Therefore, the reduction of IgE binding ability of egg white proteins during A. oryzae treatment was probably due to a loss of ~1700 Da mass including a fragment of the ovomucoid N terminus.

关键词： Aspergillus oryzae     egg allergy     egg white proteins     IgE-binding ability     ovomucoid    

HTML PDF 收藏

Influence of glucose feeding on the ligninolytic enzyme production of the white-rot fungus Phanerochaete

ZHOU Xiaoyan, WEN Xianghua, FENG Yan

《环境科学与工程前沿（英文）》 2007年 第1卷 第1期   页码 89-94 doi: 10.1007/s11783-007-0017-1

摘要： The present work studied the influence of glucose feeding on the ligninolytic enzyme production of in a nitrogen-limited (C/N ratio is 56/8.8 mmol/L) medium. Several sets of shaking flask experiments were conducted. The results showed that 2 g/L glucose feeding on the first day of the culture (24 h after the inoculation) stimulated both fungal biomass growth and enzyme production. The manganese peroxidase (MnP) activity was 2.5 times greater than that produced in cultures without glucose feeding. Furthermore, the glucose feeding mode in fed-batch culture was also investigated. Compared to cultures with glucose feeding every 48 h, cultures with glucose feeding of 1.5 g/L (final concentration) every 24 h produced more enzymes. The peak and total yield of MnP activity were 2.7 and 3 times greater compared to the contrast culture, respectively, and the enzyme was kept stable for 4 days with an activity of over 200 U/L.

关键词： enzyme production     fed-batch culture     nitrogen-limited     inoculation     mmol/L    

HTML PDF 收藏

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

《医学前沿（英文）》 2019年 第13卷 第6期   页码 741-746 doi: 10.1007/s11684-017-0579-7

摘要： Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m ). HUA was defined as serum uric acid>420 µmol/L in men and>360 µmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.

关键词： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

HTML PDF 收藏

Implicit Heaviside filter with high continuity based on suitably graded THB splines

《机械工程前沿（英文）》 2022年 第17卷 第1期   页码 14-14 doi: 10.1007/s11465-021-0670-2

摘要： The variable density topology optimization (TO) method has been applied to various engineering fields because it can effectively and efficiently generate the conceptual design for engineering structures. However, it suffers from the problem of low continuity resulting from the discreteness of both design variables and explicit Heaviside filter. In this paper, an implicit Heaviside filter with high continuity is introduced to generate black and white designs for TO where the design space is parameterized by suitably graded truncated hierarchical B-splines (THB). In this approach, the fixed analysis mesh of isogeometric analysis is decoupled from the design mesh, whose adaptivity is implemented by truncated hierarchical B-spline subjected to an admissible requirement. Through the intrinsic local support and high continuity of THB basis, an implicit adaptively adjusted Heaviside filter is obtained to remove the checkboard patterns and generate black and white designs. Threefold advantages are attained in the proposed filter: a) The connection between analysis mesh and adaptive design mesh is easily established compared with the traditional adaptive TO method using nodal density; b) the efficiency in updating design variables is remarkably improved than the traditional implicit sensitivity filter based on B-splines under successive global refinement; and c) the generated black and white designs are preliminarily compatible with current commercial computer aided design system. Several numerical examples are used to verify the effectiveness of the proposed implicit Heaviside filter in compliance and compliant mechanism as well as heat conduction TO problems.

关键词： topology optimization     truncated hierarchical B-spline     isogeometric analysis     black and white designs     Heaviside filter    

HTML PDF 收藏

Lightweight design of an electric bus body structure with analytical target cascading

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0718-y

摘要： Lightweight designs of new-energy vehicles can reduce energy consumption, thereby improving driving mileage. In this study, a lightweight design of a newly developed multi-material electric bus body structure is examined in combination with analytical target cascading (ATC). By proposing an ATC-based two-level optimization strategy, the original lightweight design problem is decomposed into the system level and three subsystem levels. The system-level optimization model is related to mass minimization with all the structural modal frequency constraints, while each subsystem-level optimization model is related to the sub-structural performance objective with sub-structure mass constraints. To enhance the interaction between two-level systems, each subsystem-level objective is reformulated as a penalty-based function coordinated with the system-level objective. To guarantee the accuracy of the model-based analysis, a finite element model is validated through experimental modal test. A sequential quadratic programming algorithm is used to address the defined optimization problem for effective convergence. Compared with the initial design, the total mass is reduced by 49 kg, and the torsional stiffness is increased by 17.5%. In addition, the obtained design is also validated through strength analysis.

关键词： electric vehicle     body in white (BIW)     lightweight     analytical target cascading (ATC)    

HTML PDF 收藏

中国航天发展的里程碑——《中国的航天》白皮书

郭宝柱

《中国工程科学》 2006年 第8卷 第10期   页码 1-5

摘要：

《中国的航天》白皮书是中国政府首次全面、系统地向全世界公开介绍中国航天的发展战略和有关政策，白皮书的发布是中国航天史的一件意义重大、影响深远的里程碑事件。文章介绍了白皮书中一些重要的新概念的形成过程，包括“大航天”的内涵、不同领域在航天活动中的作用和定位等，并简要阐述了由此引出的航天发展的相关政策以及民用航天近期发展思路和规划等。

关键词： 中国航天白皮书     大航天     航天政策    

HTML PDF 收藏

Review of the damage mechanism in wind turbine gearbox bearings under rolling contact fatigue

Yun-Shuai SU, Shu-Rong YU, Shu-Xin LI, Yan-Ni HE

《机械工程前沿（英文）》 2019年 第14卷 第4期   页码 434-441 doi: 10.1007/s11465-018-0474-1

摘要： Wind turbine gearbox bearings fail with the service life is much shorter than the designed life. Gearbox bearings are subjected to rolling contact fatigue (RCF) and they are observed to fail due to axial cracking, surface flaking, and the formation of white etching areas (WEAs). The current study reviewed these three typical failure modes. The underlying dominant mechanisms were discussed with emphasis on the formation mechanism of WEAs. Although numerous studies have been carried out, the formation of WEAs remains unclear. The prevailing mechanism of the rubbing of crack faces that generates WEAs was questioned by the authors. WEAs were compared with adiabatic shear bands (ASBs) generated in the high strain rate deformation in terms of microstructural compositions, grain refinement, and formation mechanism. Results indicate that a number of similarities exist between them. However, substantial evidence is required to verify whether or not WEAs and ASBs are the same matters.

关键词： rolling contact fatigue (RCF)     white etching area (WEA)     white etching crack (WEC)     adiabatic shear band (ASB)    

HTML PDF 收藏

Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion

Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong

《医学前沿（英文）》 2021年 第15卷 第1期   页码 125-138 doi: 10.1007/s11684-019-0725-5

摘要： This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls (HC) using the anisotropic effect size–signed differential mapping. A total of 808 patients with PD and 760 HC coming from 27 databases were finally included. Subgroup analyses were conducted considering heterogeneity with respect to medication status, disease stage, analysis methods, and the number of diffusion directions in acquisition. Compared with HC, patients with PD had decreased FA in the left middle cerebellar peduncle, corpus callosum (CC), left inferior fronto-occipital fasciculus, and right inferior longitudinal fasciculus. Most of the main results remained unchanged in subgroup meta-analyses of medicated patients, early stage patients, voxel-based analysis, and acquisition with ＜30 diffusion directions. The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex. The cerebellum and CC, associated with typical motor impairment, showed the most consistent FA decreases in PD. Medication status, analysis approaches, and the number of diffusion directions have an important impact on the findings, needing careful evaluation in future meta-analyses.

关键词： Parkinson’s disease     diffusion tensor imaging     fractional anisotropy     meta-analysis     anisotropic effect size–signed differential mapping    

HTML PDF 收藏

Bio-modification of eucalyptus chemithermomechanical pulp

YANG Qifeng, ZHAN Huaiyu, FU Shiyu, WANG Shuangfei, LI Kecheng

《化学科学与工程前沿（英文）》 2008年 第2卷 第1期   页码 28-33 doi: 10.1007/s11705-008-0007-2

摘要： Eucalyptus chemithermomechanical pulp (CTMP) was modified with the white-rot fungus 19-6 in a stationary culture condition. Different factors that influence the effect of white-rot fungus treatment, including additional nutrition, pH value, temperature, treatment time and oxygen input were investigated. The results show that the energy consumption of post refining of CTMP treated by white-rot fungus 19-6 was lower than that of untreated pulp and the strength properties also obviously improved. At a freeness level of about 330 mL, compared to the untreated pulp, the tensile index, tear index and internal bonding strength increased by 21.3%, 27.4% and 33.1%, respectively. Unfortunately, the treatment with white-rot fungus substantially decreased all optical properties except for opacity, which was essentially unchanged. Brightness and light scattering coefficient were reduced to as much as 25% and 21% compared to the untreated pulps. However, after a tow-stage “NaSO–HO” bleaching, the final brightness can reach 70.3% ISO, which is similar to that of the untreated CTMP.

关键词： Different     white-rot     NaSO–HO     unchanged     strength    

HTML PDF 收藏

粉煤灰提取白炭黑和氧化铝的研究

荆富,伊茂森,张忠温,饶拴民

《中国工程科学》 2012年 第14卷 第2期   页码 96-106

摘要：

粉煤灰是我国当前排量最大的工业废渣之一，年排渣量已达3亿t以上，大量堆积的粉煤灰会对自然生态环境造成严重的危害。综合利用粉煤灰，实现粉煤灰的资源化利用，对于治理粉煤灰的污染具有十分重要的意义。文章提出先采用碱液常压浸出粉煤灰，生产白炭黑，然后采用碱石灰烧结法生产氧化铝，可实现粉煤灰的经济综合利用。研究表明：用苛性碱液在常压（＜125 ℃）下浸取粉煤灰45 min，粉煤灰中硅的提取率达到72.5 %以上，而氧化铝的总溶出率＜1.2 %；碳分浸取得到的硅酸钠溶液，可以生产氧化硅含量＞99 %的优质白炭黑，溶液中氧化硅转化率＞98 %；浸取硅后的渣中氧化铝含量＞55 %，氧化硅含量＜20 %，铝硅比≥2.7，适宜采用碱石灰烧结法生产氧化铝。碱石灰烧结法适宜的配方为：碱比 0.95～1.0，钙比 1.8～2.0；烧结温度宜为1 200～1 250 ℃；熟料溶出温度75～85 ℃，时间10～20 min，氧化铝回收率＞86 %。综合利用粉煤灰生产白炭黑和氧化铝，经济效益和社会效益显著。

关键词： 粉煤灰     白炭黑     氧化铝     综合利用    

HTML PDF 收藏

标题 作者 时间 类型 操作

Medical applications of phytoestrogens from the Thai herb

null

期刊论文

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

期刊论文

Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

期刊论文

A microarray study of altered gene expression during melanoblasts migration in normal pigmented White

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

期刊论文

control of structural responses using an optimal passive tuned mass damper under stationary Gaussian white

Min-Ho CHEY, Jae-Ung KIM

期刊论文

reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

期刊论文

Influence of glucose feeding on the ligninolytic enzyme production of the white-rot fungus Phanerochaete

ZHOU Xiaoyan, WEN Xianghua, FENG Yan

期刊论文

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

期刊论文

Implicit Heaviside filter with high continuity based on suitably graded THB splines

期刊论文

Lightweight design of an electric bus body structure with analytical target cascading

期刊论文

中国航天发展的里程碑——《中国的航天》白皮书

郭宝柱

期刊论文

Review of the damage mechanism in wind turbine gearbox bearings under rolling contact fatigue

Yun-Shuai SU, Shu-Rong YU, Shu-Xin LI, Yan-Ni HE

期刊论文

Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion

Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong

期刊论文

Bio-modification of eucalyptus chemithermomechanical pulp

YANG Qifeng, ZHAN Huaiyu, FU Shiyu, WANG Shuangfei, LI Kecheng

期刊论文

粉煤灰提取白炭黑和氧化铝的研究

荆富,伊茂森,张忠温,饶拴民

期刊论文